KEGG   Homo sapiens (human): 6652
Entry
6652              CDS       T01001                                 
Symbol
SORD, HEL-S-95n, HMNR8, RDH, SDH, SORD1, SORDD, XDH
Name
(RefSeq) sorbitol dehydrogenase
  KO
K00008  L-iditol 2-dehydrogenase [EC:1.1.1.14]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00040  Pentose and glucuronate interconversions
hsa00051  Fructose and mannose metabolism
hsa01100  Metabolic pathways
Module
hsa_M00014  Glucuronate pathway (uronate pathway)
Disease
H00856  Distal hereditary motor neuropathies
H02567  Sorbitol dehydrogenase deficiency with peripheral neuropathy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00040 Pentose and glucuronate interconversions
    6652 (SORD)
   00051 Fructose and mannose metabolism
    6652 (SORD)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.14  L-iditol 2-dehydrogenase
     6652 (SORD)
SSDB
Motif
Pfam: ADH_zinc_N ADH_N Glu_dehyd_C AlaDh_PNT_C ADH_zinc_N_2 DUF2921 Methyltransf_25 TrkA_N
Other DBs
NCBI-GeneID: 6652
NCBI-ProteinID: NP_003095
OMIM: 182500
HGNC: 11184
Ensembl: ENSG00000140263
UniProt: Q00796
Structure
Position
15:45023195..45077185
AA seq 357 aa
MAAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNF
IVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFC
ATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCG
AGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQL
GCKPEVTIECTGAEASIQAGIYATRSGGNLVLVGLGSEMTTVPLLHAAIREVDIKGVFRY
CNTWPVAISMLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP
NT seq 1074 nt   +upstreamnt  +downstreamnt
atggcggcggcggccaagcccaacaacctttccctggtggtgcacggaccgggggacttg
cgcctggagaactatcctatccctgaaccaggcccaaatgaggtcttgctgaggatgcat
tctgttggaatctgtggctcagatgtccactactgggagtatggtcgaattgggaatttt
attgtgaaaaagcccatggtgctgggacatgaagcttcgggaacagtcgaaaaagtggga
tcatcggtaaagcacctaaaaccaggtgatcgtgttgccatcgagcctggtgctccccga
gaaaatgatgaattctgcaagatgggccgatacaatctgtcaccttccatcttcttctgt
gccacgccccccgatgacgggaacctctgccggttctataagcacaatgcagccttttgt
tacaagcttcctgacaatgtcacctttgaggaaggcgccctgatcgagccactttctgtg
gggatccatgcctgcaggagaggcggagttaccctgggacacaaggtccttgtgtgtgga
gctgggccaatcgggatggtcactttgctcgtggccaaagcaatgggagcagctcaagta
gtggtgactgatctgtctgctacccgattgtccaaagccaaggagattggggctgattta
gtcctccagatctccaaggagagccctcaggaaatcgccaggaaagtagaaggtcagctg
gggtgcaagccggaagtcaccatcgagtgcacgggggcagaggcctccatccaggcgggc
atctacgccactcgctctggtgggaacctcgtgcttgtggggctgggctctgagatgacc
accgtacccctactgcatgcagccatccgggaggtggatatcaagggcgtgtttcgatac
tgcaacacgtggccagtggcgatttcgatgcttgcgtccaagtctgtgaatgtaaaaccc
ctcgtcacccataggtttcctctggagaaagctctggaggcctttgaaacatttaaaaag
ggattggggttgaaaatcatgctcaagtgtgaccccagtgaccagaatccctga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (3)   
   KEGG MODULE (1)   
Disease (4)   
   KEGG DISEASE (2)   
   OMIM (2)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (26)   
   KEGG ORTHOLOGY (1)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (28)   
   RefSeq(nuc) (2)   
   GenBank (13)   
   EMBL (13)   
3D Structure (3)   
   PDB (3)   
Protein domain (8)   
   Pfam (8)   
All databases (89)   

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